Diagnostic molecular pathology, part 2:
Proteomics and clinical applications of molecular diagnostics in hematopathology

Georges J. Netto, MD, and Rana Saad, PhD

Currently, molecular diagnostics plays an important role in the clinical management of a wide array of hematologic neoplasms, solid tumors, infectious diseases, and inherited genetic disorders. In this second part of our series, we conclude our review of esoteric techniques by summarizing some of the advances in the field of "proteomics." We then turn our discussion to the role of molecular technology in the diagnosis, prognostication, and clinical management of lymphoid and leukemic neoplasms. The article also addresses the crucial role of molecular diagnostics in monitoring engraftment status following marrow transplantation.