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Function CYP1A2 CYP2C19 CYP2C9 CYP2D6 CYP2E1 CYP3A4
Substrates of isozyme: caffeine
clozapine
cyclobenzaprine
fluvoxamine
imipramine
mexiletine
olanzapine
pimozide
propranolol
tacrine
theophylline
warfarin		 amitriptyline
citalopram
clominpramine
cyclophosphamide
diazepam
imipramine
lansoprazole
nelfinavir
omeprazole
phenytoin		 amitriptyline
(demethylation)
celecoxib
diclofenac
flurbiprofen
ibuprofen
losartan
(not candesartan)
naproxen
phenytoin
piroxicam
sufamethoxazole
tolbutamide
warfarin		 amitriptyline
clominpramine		 acetaminophen
chlorzoxazone
dapsone
enflurance
ethanol
halothane
isoflurane
isoniazid		 alprazolam
astemizole
buspirone
calcium channel blockers
carbamazepine
cisapride
cyclosporine
doxorubicin
erythromycin
etoposide
felodipine
fentanyl
HIV protease inhibitors
ifosphamide
lovastatin
(not pravastatin)
midazolam
nifedipine
pimozide
quinidine
quinine
simvastatin
tacrolimus
terfenadine
triazolam
Inhibitors of isozyme: cimetidine
ciprofloxacin
citalopram
diltiazem
enoxacin
erythromycin
fluvoxamine
mexiletine
ofloxacin
tacrine
ticlopidine		 cimetidine
felbamate
fluoxetine
fluvoxamine
ketoconazole
lansoprazole
omeprazole
paroxetine
ticlopidine		 amiodarone
fluconazole
fluoxetine
fluvastatin
isoniazid
metronidazole
paroxetine
phenylbutazone
sulfamethoxazole/
trimethoprim
sulfaphenazole
ticlopidine		 amiodarone
chlorpheniramine
fluoxetine
haloperidol
indinavir
paroxetine
propafenone
quinidine
ritonavir
sertraline
thioridazine
ticlopidine		 disulfiram
water cress		 cimetidine
cimetidine
cyclosporine
danazol
diltiazem
fluconazole
(large doses)
grapefruit juice
HIV protease inhibitors
itraconazole
ketoconazole
macrolides
(not azithromycin)
miconazole
nefazadone
omeprazole
quinidine
ritonavir
verapamil
Inducers of isozyme: carbamazepine
tobacco		 carbamazepine
|norethindrone
(not phenobarb.)		 phenobarbital
rifampin
secobarbital		   chronic ethanol
isoniazid
tobacco		 carbamazepine
rifabutin
rifampin
ritonavir
*Table compiled references 1, 2, 4, 8.