Lawrence Sweetman, Ph.D
Director of the Mass Spectrometry Laboratory
Contact Information:
Phone: 214-820-3895
Education:
Ph.D. Biochemistry, University of Miami, Florida
American Board of Medical Genetics, Biochemical Geneticist
Research Interests:
• Novel treatments for fatty acid oxidation disorders and other metabolic disorders involving energy metabolism
• Expand the range of metabolic disorders that can be detected by tandem MS newborn screening
• Develop additional diagnostic tests for inborn errors of metabolism using HPLC/MS/MS and GCMS technology
Current Research:
• Biochemical responses (organic acids and acylcarnitines) in clinical studies of triheptanoin (anaplerotic substrate) for nutritional therapy of long-chain fatty acid oxidation disorders
• Develop HPLC MS/MS assays for different isomers of acylcarnitines for differential diagnosis of abnormal elevations seen in tandem MS newborn screening
Representative Publications:
Yu, W., Liang, X., Ensenauer, R.E., Vockley, J., Sweetman, L., and Schulz, H. Leaky beta-oxidation of a trans-fatty acid: Incomplete beta-oxidation of elaidic acid is due to the accumulation of 5-trans-tetradecenoyl-CoA and its hydrolysis and conversion to 5-trans-tetradecenoylcarnitine in the matrix of rat mitochondria. J. Biol. Chem. 279, 52160-52167, 2004.
Whitfield, J., Smith, T., Sollohub, H., Sweetman, L., and Roe, C.R. Clinical effects of L-carnitine supplementation of apnea and growth in very low birth weight infants. Pediatrics 111, 47-482, 2003.
Roe, C.R., Sweetman, L., Roe, D.S., David, F., Brunengraber, H. Effective Dietary Treatment of Cardiomyopathy & Rhabdomyolysis in Long-Chain Fax Oxidation Disorders using an Anaplerotic Odd-Chain Triglyceride. J. Clin. Invest. 110 (2): 259-269, 2002.
Sweetman, L and Williams, J: Branched Chain Organic Acidurias. The Metabolic and Molecular Basis of Inherited Diseases, 8th edition, Chapter 93, pp 2125-2164, McGraw-Hill, 2001 |
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