Charles R. Roe, M.D.
Medical Director of Institute of Metabolic Disease
Professor of Biomedical Studies, Baylor University
Contact Information:
Phone: 214-820-4855
Education:
B.A. Duke University
M.D. Duke University Medical Center
Biochemistry Dept, Brandeis University
Residency/Fellowship in Pediatric Metabolism, Duke University
Research Interests:
• Biochemical Genetics- Fat Oxidation, Organic Acidurias, Glycogenoses
• Acquired Metabolic Disorders of Children and Adults
• Investigation for Developing More Effective Treatment of Fat Oxidation Defects, Organic Acidurias, and Glycogenoses
Current Research:
Collaborative studies nationally and internationally for development of new effective therapies for inherited and acquired disorders of metabolism. Current emphasis is on disorders affecting branched-chain amino acids, fat oxidation, and glycogenoses.
Ongoing Research Studies:
The Institute of Metabolic Disease at Baylor is currently conducting a research study entitled, “Dietary Therapy for Inherited Disorders of Mitochondrial Fat Oxidation and Glycogenoses.”
To learn more about the study, contact Dr. Roe or Mary Wallace at (214) 820-4533.
Representative Publications:
Mochel, F., DeLonlay, P., Touati, G., Brunengraber, H., Kinman, R., D., Roe, C.R., Saudubray, J. Pyruvate Carboxylase deficiency: clinical and biochemical response to anaplerotic diet therapy. Molecular Genetics and Metabolism. Volume 84: 305-312, 2005.
Roe, C.R. and Ding, J.H.: Mitochondrial Fatty Acid Oxidation Disorders. The Metabolic and Molecular Bases of Inherited Diseases, 8th edition, Chapter 101, pp 2297-2326, McGraw-Hill, 2001.
Roe, C.R., Sweetman, L., Roe, D.S., David, F., Brunegraber, H. Effective Dietary Treatment of Cardiomyopathy & Rhabdomyolysis in Long-Chain Fax Oxidation Disorders using an Anaplerotic Odd-Chain Triglyceride. J. Clin. Invest 110 (2): 259-269, 2002. |
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