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Institute of Metabolic Disease at Baylor Research Institute
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Excitatory sulfur amino acids
Excitatory sulfur amino acids (ESAA) include homocysteic acid (HCA), homocystiene sulfinic acid (HSA), cysteic acid (CA) and cysteine sulfinic acid (CSA). These amino acids promote neurotoxicity through activation of N-methyl-D-asparate (NMDA) receptors. Increased levels of HCA and CSA have been shown to be associated with hyperhomocysteinemia due to methotrexate therapy.
Department: Neuropharmacology
Methodology: HPLC and fluorescence detection
Sample:
• Plasma – 0.25mL heparinized plasma
• Serum – 0.25 mL
• Cerebrospinal fluid – 0.25 mL
Handling:
• Plasma and Serum -spin down the sample within 1 hour of collection.
• Cerebrospinal Fluid - freeze CSF immediately and store at -80°C until transport.
Shipping:
• Plasma, Serum - Ship sample overnight with 3-4 lbs of dry ice using a guaranteed overnight courier.
• CSF – Ship Monday through Wednesday only. Ship sample overnight with 3-4 lbs of dry ice using a guaranteed overnight courier.
Special Notes: This research test must be coordinated through the Neuropharmacology Laboratory Director. Most research tests are performed on a batch basis; the laboratory will not perform single sample testing. Contact the Neuropharmacology Laboratory Director for more information.
Turnaround Time and Test Cost: Contact the Neuropharmacology Laboratory Director
Related tests: Homocysteine-Research |
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