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Institute of Metabolic Disease at Baylor Research Institute
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Asymmetric dimethylarginine (ADMA)
Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of the enzyme nitric oxide synthetase (NOS), which regulates levels of nitric oxide (NO). NO itself is a key molecule in the regulation of cellular responses including endothelial vasodilation. Plasma levels of ADMA have been reported to be indirectly related to the activity of nitric oxide and vascular function. Increase levels of plasma ADMA have been shown to be associated with vascular disease, renal insufficiency, diabetes, and hyperthyroidism. Increased plasma ADMA is also found in subjects with hyperhomocysteinemia and folate deficiency.
Department: Neuropharmacology
Methodology: HPLC and fluorescence detection
Sample:
• Plasma – 0.25mL heparinized plasma
• Serum – 0.25 mL
• Cerebrospinal fluid – 0.25 mL
Handling:
Plasma and Serum -spin down the sample within 1 hour of collection.
Cerebrospinal Fluid - freeze CSF immediately and store at -80°C until transport.
Shipping:
• Plasma and Serum - Ship sample overnight with 3-4 lbs of dry ice using a guaranteed overnight courier.
• CSF – Ship sample Monday through Wednesday only. Ship sample overnight with 3-4 lbs of dry ice using a guaranteed overnight courier.
Special Notes: This research test must be coordinated through the Neuropharmacology Laboratory Director. Most research tests are performed on a batch basis; the laboratory will not perform single sample testing. Contact the Neuropharmacology Laboratory Director for more information.
Turnaround Time and Test Cost: Contact the Neuropharmacology Laboratory Director.
Related tests: Homocysteine-Research, Folate (total), Vitamin B12, Vitamin B6 |
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