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Institute of Metabolic Disease at Baylor Research Institute
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Apolipoprotein A1 (Apo A1)
Lipids are found in plasma in the form of packages such as low density lipoprotein (LDL), very low density lipoprotein (VLDL), and high density lipoprotein (HDL). These packages, along with the lipids themselves, also contain carrier proteins called apolipoproteins. There are several principal apolipoproteins with A-1 and B being present in the highest concentrations. Apo A-1 constitutes approximately 70% of the protein in HDL and 35% of the total HDL mass. Apo A-1 in HDL is anti-atherogenic. Apo A-1 concentrations are elevated on a genetic basis.
Other factors such as diet, exercise, and drugs such as niacin and thyroid hormones may also increase levels. Recent studies show that the Apo B to Apo A-1 ratio correlates much better with an increased risk of CAD than does total serum cholesterol, LDL:HDL cholesterol ratio, or individual lipoprotein levels
Department: Neuropharmacology
Methodology: Nephalometric detection
Sample:
• Plasma – 0.5 mL of heparinized plasma
• Serum – 0.5 mL
Shipping/Handling:
For both sample types, spin down the sample within 1 hour of collection. Freeze sample and ship overnight on 3-4 lbs of dry ice.
Special Notes: This research test must be coordinated through the Neuropharmacology Laboratory Director. Most research tests are performed on a batch basis; the laboratory will not perform single sample testing. Contact the Neuropharmacology Laboratory Director for more information.
Turnaround Time and Test Cost: Contact the Neuropharmacology Laboratory Director.
Related tests: Apolipoprotein B, Lipoprotein (a), hs-C Reactive Protein, Homocysteine (total)
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