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Institute of Metabolic Disease at Baylor Research Institute
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Neopterin
Neopterin is a catabolic product of guanosine triphosphate (GTP) and the synthesis of tetrahydrobiopterin (BH4). It is predominantly produced by macrophages and measurement in cerebrospinal fluid provides information about activation of the cellular immune system. Increased neopterin production is found in, but not limited to: viral infections including HIV, bacterial infections, autoimmune disease and malignant tumor diseases. Changes in CSF neopterin may also occur in deficiency of the BH4 synthesis pathway.
Download Protocol Sheet and Test Requisition
Department: Neuropharmacology
Methodology: HPLC with fluorescence detection
Sample:
Cerebrospinal Fluid - 0.5 ml
Handling:
Freeze CSF immediately and store at -80°C until transport.
Shipping:
Ship sample Monday through Thursday only.
Ship sample overnight with 3-4 lbs of dry ice using a guaranteed overnight courier
Cost: $125.00
CPT code: 82491
Turnaround Time: 1 week from receipt of sample.
Related tests: Tetrahydrobiopterin & Neopterin Profile, Monoamine Neurotransmitter metabolites
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