Assistant Investigator   Contact Information   3310 Live Oak Street Dallas, TX, 75204 (214) 818-9634 wei.lin@baylorhealth.edu

 

 

Education and Training

 

Postdoctoral, Genomics and Epigenomics

Lab of Population Genetics

National Cancer Institute, NIH

 

PhD, Computational Biology

Department of Biological Science and Biotechnology

Tsinghua University, Beijing, China

 

BS, Chemistry

Department of Chemistry

Central South University of Technology, Hunan, China

 

Experience

 

Assistant Investigator

Baylor Institute for Immunology Research, Dallas, TX

 

Sci. Informatics Analyst III

Lab of Functional Genomics, Cold Spring Harbor Lab, NY

 

Sr. Biomedical Informatics Scientist

Contractor to NCI Center of Bioinformatics, NIH,

SRA International and SAIC, Rockville, MD

 

Research Interests

 

My research focuses on genome research of immunology as well as development of methodology of high-throughput data analysis.

 

• Development of new technology based on Next-Generation Sequencing
• Study the genomic and transcriptomic variation associated with autoimmune disease, immune response, cancer vaccine
• Development of robust tools for extensive analyses of high-dimensional data from Next-Generation Sequencing
• Develop statistical model of genome analysis

 

Major Contributions to Science

 

Involvement of ENCODE project. ENCODE is international collaboration of research funded by National Human Genome Research.  The goal is to build a comprehensive parts list of functional elements in human genome.

 

• Djebali, S., ....Lin, W., ....et al., Landscape of transcription in human cell.  Nature. 489: 101-108, 2012.

 

• ENCODE consortium. An integrated Encyclopedia of DNA Elements in the Human Genome. Nature. 489: 57-74, 2012.

 

• Mouse ENCODE consortium. An encyclopedia of mouse DNA elements (Mouse ENCODE). Genome Biology. 13:418, 2012.

 

Involvement of ModENCODE project. ModENCODE project shares the same goal as ENCODE of identification of functional elements. It focuses on two major model organisms, C. elegans and D. melanogaster.

 

• Graveley, B.R.,...Lin W., ...et al., The developmental transcriptome of Drosophila melanogaster. Nature,  2011. 471 (7339): p. 473-9.

 

• Cherbas, L., ...Lin W., ...et al., The transcriptional diversity of 25 Drosophila cell lines. Genome Res, 2011. 21 (2): p. 301-14.

 

• Roy, S., ...Lin W., ... et al., Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science, 2010. 330 (6012): p. 1787-97.

 

Identified common technical artifact of RNA-seq mapping. Developed robust pipeline to identify RNA-seq variant.

 

• *Ramaswami, G., *Lin, W., et al., Accurate identification of human Alu and non-Alu RNA editing sites.  Nature Method. 2012, 9 p. 579-581. (co-first author)

 

• Lin, W., et al., Comment on "Widespread RNA and DNA Sequence Differences in the Human Transcriptome. Science. 2012, 335 (6074): p. 1302.

 

Publications (total 13 from 2002 to 2012)

 

Key publications during the past 5 years (2007-2012)

 

• Mouse ENCODE consortium. An encyclopedia of mouse DNA elements (Mouse ENCODE). Genome Biology. 13:418, 2012.

 

• Djebali, S., ....Lin, W., ....et al., Landscape of transcription in human cell.  Nature. 489: 101-108, 2012.

 

• ENCODE consortium.  An integrated Encyclopedia of DNA Elements in the Human Genome. Nature. 489: 57-74, 2012.

 

• *Ramaswami, G., *Lin, W., et al., Accurate identification of human Alu and non-Alu RNA editing sites.  Nature Method. 9: 579-581, 2012. (co-first author)

 

• Lin, W., et al., Comment on "Widespread RNA and DNA Sequence Differences in the Human Transcriptome. Science. 2012, 335 (6074): p. 1302.

 

• Graveley, B.R.,...Lin W., ...et al., The developmental transcriptome of Drosophila melanogaster. Nature,  2011. 471 (7339): p. 473-9.

 

• Cherbas, L., ...Lin W., ...et al., The transcriptional diversity of 25 Drosophila cell lines. Genome Res, 2011. 21 (2): p. 301-14.

 

• Roy, S., ...Lin W., ... et al., Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science, 2010. 330 (6012): p. 1787-97.

 

Current Grants

 

Harnessing Human DC Subsets for Improved Mucosal Vaccines

NIH/NIAID, U19 AI057234

09/30/03 - 04/01/14

(Sub project Co-Pl: The origin and the fate of flu-specific Tfh cells in flu vaccination)