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SangKon Oh, PhD

 

Investigator

Adjunct Professor at

Baylor University

Waco, Texas

 

CONTACT INFORMATION

 

3434 Live Oak Street

Dallas, TX 75204

(214) 820-7474

 

Sangkono@BaylorHealth.edu

 

EDUCATION

 

BS, Pusan National University, Pusan, Korea

MS, Pusan National University, Pusan, Korea

PhD, Johns Hopkins University, Baltimore, MD

 

 

MAJOR CONTRIBUTIONS TO SCIENCE

 

Dr. SangKon Oh received his PhD degree at the Johns Hopkins University in 2000 and trained at National Cancer Center (NCI, NIH) as a postdoctoral fellow by 2002. He worked as an IPA fellow at NCI in association with the Johns Hopkins University from 2002 to 2005. Dr. Oh joined BIIR in 2005. He is also affiliated with Baylor University at Waco, TX, as an Associate Professor.

 

Dr. Oh’s laboratory studies on the molecular and immunological functions of DC surface receptors expressed on different subsets of human dendritic cells in healthy and patients. Dr. Oh laboratory has uncovered novel immunological functions of several DC surface lectins, e.g. DC-ASGPR and LOX-1, in controlling host immune responses toward either immunity or tolerance. Dr. Oh’s laboratory has also discovered that monocytes and subsets of DCs in lupus patients express distinct patterns of surface receptors, which could help us understand the mechanisms in which DCs break B cell tolerance in lupus.

 

Dr. Oh’s researches will eventually help us design effective vaccines against cancers and microbial infections as well as immunotherapeutics for autoimmune diseases.

 

 

CURRENT GRANTS

             

Antibody-Based Combination Therapy against Prostate Cancer

American Cancer Society

2/01/11 – 11/31/15

 

Controlling Allergen-Specific Th2-Type Responses by Targeting DC Surface Receptors

National Institute of Allergy & Infectious Diseases (1R21AI101810-010)

07/01/2012-06/30/2015

 

DC-ASGPR as a Novel Target for Controlling GVHD and Allograft Rejection

National Institute of Allergy & Infectious Diseases (1R01AI105066)

04/01/2013-03/31/2018

 

Antibody-based combination immunotherapy against prostate cancer

American Cancer Society (RSG-12-075-01-LB)

01/01/12 – 12/31/15

 

Analysis of Immune profile of asthma patients treated with Xoliar

Genentech

11/1/2013 – 10/30/2015

 

 

PUBLICATIONS (total 43 from 2000 to 2012)

Key publications during the past 5 years (2009-2014)

 

1.    Dullaers, M., Li, D., Xu, Y., Ni, L., Gayet, I., Morita, R., Ueno, H., Palucka, A.K., Banchereau, J., and Oh, S.  (2009). A T cell-dependent mechanism for the induction of human mucosal homing immunoglobulin A-secreting plasmablasts.  Immunity.  30: 120-129.

2.    Ni, L., Gayet, I., Zurawski, S., Duluc, D., Flamar, A.L., Li, X.H., O'Bar, A., Clayton, S., Palucka, A.K. Zurawski, G., Banchereau, J., Oh, S. (2010). Concomitant activation and antigen uptake via human Dectin-1 results in potent antigen-specific CD8+ T cell responses. J. Immunol. 185: 3504-3513.

3.    Ueno, H., Schmitt, N., Klechevsky, E., Pedroza-Gonzalez, A., Matsui, T., Zurawski, G., Oh, S., Fay, J., Pascual, V., Banchereau, J., and Palucka, K. (2010). Harnessing human dendritic cell subsets for medicine. Immunol Rev. 234:199-212.

4.    Morita, R., Schmitt, N., Bentebibel, S.E., Ranganathan, R., Bourdery, L., Zurawski, G., Foucat, E.,      Dullaers, M., Oh, S., Sabzghabaei, N., Lavecchio, E.M., Punaro, M., Pascual, V., Banchereau, J., and Ueno, H. (2011). Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and   Contain Specific Subsets that Differentially Support Antibody Secretion. Immunity. 34:108-21.

5.    Ueno, H., Klechevsky, E., Schmitt, N., Ni, L., Flamar, A.L., Zurawski, S., Zurawski, G., Palucka, K.,   Banchereau, J., and Oh, S.  (2011). Targeting human dendritic cell subsets for improved vaccines. Semin. Immunol. 23:21-7.

6.    Li, D., Romain, G., Flamar, A.L., Duluc, D., Dullaers, M., Li, X.H., Zurawski, S., Bosquot, N., Palucka,      A.K., Le Grand, R., O’Garra A., Zurawski, G., Banchereau, J., Oh, S. (2012). Targeting self- and foreign-antigens to dendritic cells via DC-ASGPR generates IL-10-producing suppressive CD4+ T cells. J. Exp.   Medicine 209:109-21.

7.    Romain, G., van Gulck, E., Epaulard, O., Oh, S., Li, D., Zurawski, G., Zurawski, S., Cosma, A., Adam, L., Chapon, C., Todorova, B., Banchereau, J., Dereuddre-Bosquet, N., Vanham, G., Le Grand, R., Martinon, F. (2012). CD34-derived dendritic cells transfected ex vivo with HIV-Gag mRNA induce polyfunctional T-cell responses in nonhuman primates. Eur J. Immunol. May, 2012.

8.    Joo, H, Coquery, C., Xue, Y., Gayet, I., Dillon, S., Punaro, M., Zurawski, G., Banchereau, J., Pascual, V., and Oh, S. (2012). Serum from patients with SLE instructs monocytes to promote IgG and IgA   plasmablast differentiation. J. Exp. Medicine. July, 2012.

9.    Martirosyan, A., Pérez-Gutierrez, C., Banchereau, R., Dutartre, H., Lecine, P., Dullaers, M. Mello,M., Pinto Salcedo, S., Muller, A., Leserman, L., Levy, Y., Zurawski, G., Zurawski, S., Moreno, E., Moriyón, I., Klechevsky, E., Banchereau, J. Oh, S., Gorvel, J.P. (2012). Brucella beta-1,2-cyclic glucan is an activator of human and mouse dendritic cells. PLoS Pathog. 8: e1002938. PMCID: PMC3499565.

10.   Xu, W., Joo, H., Clayton, S., Dullaers, M., Herve, M.C., Blankenship, D., De La Morena M.T., Baldera, S R., Picard, C., Casanova, J.L., Pascual, V., Oh, S., Banchereau, J. (2012). Macrophages induces differentiation of plasma cells through CXCL10/IP-10. J Exp Med. 209: 1813-23. PMCID: PMC3457728.

11.   Martirosyan, A., Ohne, Y., Degos, C., Gorvel, L., Moriyón, I., Oh, S., Gorvel, J.P. (2013). Lipopolysaccharides with acylation defects potentiate TLR4 signaling and shape T cell responses. PLoS One 8: e55117.

12.   Flamar AL, Xue Y, Zurawski SM, Montes M, King B, Sloan L, Oh S, Banchereau J, Levy Y, Zurawski G. (2013)  Targeting concatenated HIV antigens to human CD40 expands a broad repertoires of multifunctional CD4+ and CD8+ T cells. AIDS 27:2041-51.

13.   Duluc, D., Gannevat, J., Joo, H., Ni, L., Upchurch, K., Boreham, M., Carley, M., Stecher, J., Zurawski, G., Oh, S. (2013). Dendritic cells and vaccine design for sexually-transmitted diseases. Microb Pathog: 58: 35-44.

14.   Duluc, D., Gannevat, J., Anguiano, E., Zurawski, S., Carley, M., Boreham, M., Stecher, J., Dullaers, M., Banchereau, J., Oh, S. (2013) Functional diversity of human vaginal APC subsets in directing T-cell responses. Mucosal Immunol. 104: 1-13.

15.   Xu W, Narayanan P, Kang N, Clayton S, Ohne Y, Shi P, Herve MC, Balderas R, Picard C, Casanova JL,   Gorvel JP, Oh, S, Pascual V, Banchereau J (2014) Human plasma cells express granzyme B. Eur J. Immunol.44 : 275-84.

16.   Duluc, D., Joo, H., Ni, L., Yin W., Upchurch K., Li, D., Xue, Y., Klucar, P., Zurawski, S., Zurawski, G., and Oh S. (2014)  Induction and activation of human Th17 by targeting antigens to dendritic cells via Dectin-1. J. Immunology. June, 2014.

17.   Wu, T.C., Xu, K., Banchereau, R., Marches, F,, Yu, C.I., Martinek, J., Anguiano E, Pedroza-Gonzalez A, Snipes, G,J,, O'Shaughnessy, J., Nishimura, S., Liu, Y.J., Pascual, V., Banchereau,  J., Oh, S., and Palucka, K. (2014). Reprogramming tumor-infiltrating dendritic cells for CD103+ CD8+ mucosal T-cell differentiation and breast cancer rejection. Cancer Immunol  Res.2:487-500

18.   Joo HM., Li D., Dullaers M., Kim TW., Duluc D., Upchurch K., Xue Y., Zurawski S., Grand RL., Liu YJ., Kuroda M., Zurawski G., Oh S. 2014. C-Type Lectin-Like Receptor LOX-1 Promotes Dendritic Cell-Mediated Class-Switched B Cell Responses in Humans. Immunity 2014.

 

 

 



Baylor Health Care System is located in Dallas, Texas