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Nicole Baldwin, PhD


Assistant Investigator


Contact Information


3434 Live Oak Street

Dallas, TX 75204

(214) 820-9621 



PhD, University of Texas Health Science Center, Houston TX
MS, University of Tennessee, Knoxville TN



Major Contributions to Science


1.  Discovery of usage of two distinct ‘wild-type’ clones of Escherichia

     coli sigma70


  • Isolation and characterization of mutations in region 1.2 of Escherichia coli sigma70. N. Baldwin, A. Dombroski. Mol Microbiol.  2001.  Oct; 42(2):427-37.


  • Two "wild-type" variants of Escherichia coli sigma70: context-dependent effects of the identity of amino acid 149. N. Baldwin, A. McCracken, A. Dombroski. J Bacteriol.  2002.  Feb; 184(4):1192-5.


2.  Application of graph theoretical approaches to complex biological



  • A Combinatorial Approach to the Analysis of Differential Gene Expression Data: The Use of Graph Algorithms for Disease Prediction and Screening. M. A. Langston, L. Lin, X. Peng, N. E. Baldwin, C. T. Symons, B. Zhang, J.R. Snoddy. Proceedings, Critical Assessment of Microarray Data Analysis, Durham, NC, November, 2003.


  • High Performance Computational Tools for Motif Discovery. N. E. Baldwin, R. L. Collins, M. A. Langston, C. T. Symons, M. R. Leuze, B. R. Voy. Proceedings, IEEE Workshop on High Performance Computational Biology, Santa Fe, NM, April, 2004.


  • Detecting Network Motifs in Gene Co-expression Networks. X. Peng, M. A. Langston, A. M. Saxton, N. E. Baldwin, J. R. Snoddy. Proceedings, International Conference for the Critical Assessment of Microarray Data Analysis, Durham, North Carolina, November, 2004.


  • Computational, Integrative and Comparative Methods for the Elucidation of Genetic Co-Expression Networks.  N. E. Baldwin, E. J. Chesler, S. Kirov, M. A. Langston, J. R. Snoddy, R. W. Williams, B. Zhang. Journal of Biomedicine and Biotechnology 2005. 2005(2): 172-180.


  • Complex Trait Analysis of Gene Expression Uncovers Polygenic and Pleiotropic Networks that Modulate Nervous System Function. E. J. Chesler, , L. Lu, S. Shou, J. Gu, Y. Qu, J. Wang, H. C. Hsu, J. D. Mountz, N. E. Baldwin, M. A. Langston, D. W. Threadgill, K. F. Manly, R. W. Williams. Nature Genetics 2005. 2005(37): 233-242.


  • On the Relative Efficiency of Maximal Clique Enumeration Algorithms, with Applications to High-Throughput Computational Biology. F.N. Abu-Khzam, N.E. Baldwin, M.A. Langston, N.F. Samatova. Proceedings, International Conference on Research Trends in Science and Technology, Beirut, Lebanon, March 2005.


  • Genome-Scale Computational Approaches to Memory-Intensive Applications in Systems Biology. Y. Zhang, F. N. Abu-Khzam, N. E. Baldwin, E. J. Chesler, N. F. Samatova, M. A. Langston.  Proc. of SC2005, Seattle, Washington, November 2005. Waldmann, J. D. Mosca, N. Baldwin, J. A. Berzofsky, S. K. Oh. J Virol. 2007. August; 81(16): 8774–8783.


3.  Development and application of module extraction data for microarray

     data analysis


  • A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus. D. Chaussabel, C. Quinn, J. Shen, P. Patel, C. Glaser, N. E. Baldwin, D. Stichweh, D. Blankenship, L. Li, I. Munagala, L. Bennett, F. Allantaz, A. Mejias, M. Ardura, E. Kaizer, L. Monnet, W. Allman, H. Randall, D. Johnson, A. Lanier, M. Punaro, KM Wittkowski, P White, J Fay, G Klintmalm, O. Ramilo, A. K. Palucka, J. Banchereau, V. Pascual. Immunity.(2008) Jul;29(1):150-64.



Publications (total 8 from 2001-2014)

Key publications during the past five years (2009-2014)


IFN priming is necessary but not sufficient to turn on a migratory dendritic cell program in lupus monocytes.

Rodriguez-Pla A, Patel P, Maecker HT, Rossello-Urgell J, Baldwin N, Bennett L, Cantrell V, Baisch J, Punaro M, Gotte A, Nassi L, Wright T, Palucka AK, Banchereau J, Pascual V.

J Immunol. 2014 Jun 15;192(12):5586-98. doi: 10.4049/jimmunol.1301319. Epub 2014 May 14.

PMID: 24829414


Democratizing systems immunology with modular transcriptional repertoire analyses.

Chaussabel D, Baldwin N.

Nat Rev Immunol. 2014 Apr;14(4):271-80. doi: 10.1038/nri3642.

PMID: 24662387


Host immune transcriptional profiles reflect the variability in clinical disease manifestations in patients with Staphylococcus aureus infections.

Banchereau R, Jordan-Villegas A, Ardura M, Mejias A, Baldwin N, Xu H, Saye E, Rossello-Urgell J, Nguyen P, Blankenship D, Creech CB, Pascual V, Banchereau J, Chaussabel D, Ramilo O.

PLoS One. 2012;7(4):e34390. doi: 10.1371/journal.pone.0034390. Epub 2012 Apr 4.

PMID: 22496797

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