Connect with us:     
Skip Navigation Links

Gerard Zurawski, PhD

 

   

 

Investigator

 

Director, Center for Biotechnology

 

 

Contact Information

3410 Worth St., Suite 600

Dallas, TX 75246

214-818-2558

gerardz@baylorhealth.edu

 

 

Education

University of Sydney, Australia

BSc Hons Class I - Microbiology

PhD - Department of Genetics, School of Biology

 

Stanford University, California

Postdoctoral Fellow, School of Biological Sciences

 

Commonwealth Scientific and Industrial Research Organization, Canberra

Queen Elizabeth II Fellow in the Division of Plant Industry

 

 

Major Contributions to Science

 

  • Studies of the control of bacterial operons via translational regulation of transcription. [G. Zurawski, D. Elseviers, G.V. Stauffer and C. Yanofsky.  Translational control of transcription termination at the attenuator of the Escherichia coli trp operon (1978). Proc. Natl. Acad. Sci. USA, 75:  5988‑5992.]
  • Structure, function, and evolution of chloroplast DNA. [E.M. Golenberg, D.E. Giannasi, M.T. Clegg, C.J. Smiley, M. Durbin, D. Henderson and   G. Zurawski.  Chloroplast DNA from a Miocene Magnolia species (1990).  Nature, 344, 656‑658.]
  • Nature of interactions between cytokines and their receptor complexes. [S.M. Zurawski and G. Zurawski.  Receptor antagonist and selective agonist derivatives of mouse interleukin‑2 (1992). EMBO J., 11, 3905‑3910.]
  • Discovery, biology, and receptor complexes of interleukin-13. [A.N.J. McKenzie, J.A. Culpepper, R. de Waal Malefyt, F. Briere, J. Punnonen, G. Aversa, A. Sato, W. Dang, B.G. Cocks, S. Menon, J.E. de Vries, J. Banchereau, and G. Zurawski. Interleukin‑13, a novel T cell‑derived cytokine that regulates human monocyte and B cell function (1993). Proc. Natl. Acad. Sci. USA, 90, 3735‑3739.]
  • Directed a genomics program at the DNAX Research Institute that discovered numerous cytokines and their receptors, including IL-19, IL-22, IL-23, IL-25, IL-27, IL-33, and TSLP. [M.M. Fort,  J. Cheung, D. Yen, Y.-J. Liu, S.M.  Zurawski, S. Lo, S. Menon, T. Clifford, B. Hunte, R. Lesley, T. Muchamuel, S.D. Hurst, G. Zurawski, M.W. Leach, D.M. Gorman, and D.M. Rennick. IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo (2001). Immunity, 15, 985-995.]
  • Directing a program of vaccine development at BIIR based on targeting antigens directly to dendritic cells. [Dapeng LI 2012 J. Ex. Med paper]

 

 

Key Patents

 

1. Multivariable Antigens Complexed with Targeting Humanized Monoclonal Antibody. Granted patent 12/024,036

 

2. Vaccines Based on Targeting Antigen to DCIR Expressed on Antigen-Presenting Cells. Granted patent 12/024,897

 

3. Agents That Engage Antigen-Presenting Cells Through Dendritic Cell Asialoglycoprotein Receptor (DC-ASGPR). Pending patent 12/025,010

 

4. HIV Vaccine Based on Targeting Maximized Gag and Nef to Dendritic Cells. Pending patent 12/504,463

 

5. Antigen Presenting Cell Targeted Anti-Viral Vaccines. Pending patent 12/717,804

 

 

Current Grants

  

Systems Analysis of Vaccine Responses in Healthy and Hyporesponsive Humans (U19-AI089987)

National Institute of Allergy and Infectious Diseases

06/01/2010-05/31/2015

 

Developing Therapeutic and Preventive HIV Vaccines

Agence nationale de reserches sur le sida et le hépatites virales (ANRS)

09/01/2007-ongoing

 

Understanding the Early and Late Endosomal TLR9-Mediated Responses (1R01 AI097348-01)

National Institute of Allergy and Infectious Diseases

09/01/2011-08/31/2016

 

A Novel Replication-Competent Flavivirus-Based HIV Vaccine Platform, i.e. RepliVax, as a Priming Component for Improving Antibody Response

Bill & Melinda Gates Foundation

09/06/2012-08/31/2015

 

DC-ASGPR as a Novel Target for Controlling GVHD and Allograft Rejection (1R01AI105066)

National Institute of Allergy and Infectious Diseases

04/01/2013-03/31/2018

 

Characterizing DExD/H Box Helicases as Viral Sensors in Human Dendritic Cells (R37 AI091947-01)

National Institute of Allergy and Infectious Diseases

05/01/2011-04/30/2016

 

 

Publications (total of 90 from 1975-2014)

Key publications during the past 5 years (2009-2014)

 

Flamar AL, Xue Y, Zurawski SM, Montes M, King B, Sloan L, Oh S, Banchereau J, Levy Y, Zurawski G. Targeting concatenated HIV antigens to human CD40 expands a broad repertoire of multifunctional CD4+ and CD8+ T cells. AIDS. 2013 Aug 24;27(13):2041-51.

 

Flamar AL, Zurawski S, Scholz F, Gayet I, Ni L, Li XH, Klechevsky E, Quinn J, Oh S, Kaplan DH, Banchereau J, Zurawski G. Noncovalent assembly of anti-dendritic cell antibodies and antigens for evoking immune responses in vitro and in vivo. J Immunol. 2012 Sep 1;189(5):2645-55.

 

Li D, Romain G, Flamar AL, Duluc D, Dullaers M, Li XH, Zurawski S, Bosquet N, Palucka AK, Le Grand R, O'Garra A, Zurawski G, Banchereau J, Oh S. Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10-producing suppressive CD4+ T cells. J Exp Med. 2012 Jan 16;209(1):109-21.

 

Klechevsky E, Flamar A-L, Cao Y, Blanck J-P, Liu M, O'Bar A, Agouna-Deciat O, Klucar P, Thompson-Snipes L, Zurawski S, Reiter Y, Palucka AK, Zurawski G, Banchereau J. Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR. Blood 2010;116:1685-97.
 
Ni L, Li X-H, Ingrid G, Duluc D, Klucar P, Clayton S, Zurawski S, Palucka AK, Zurawski G, Banchereau J, Oh SK. The role of human Dectin-1 in eliciting antigen specific CD8+ T cell responses. 
J Immunol 2010;184 :130-5.
 
Ni L, Gayet I, Zurawski S, Duluc D, Flamar A-L, Li X-H, O’Bar A, Clayton S, Palucka AK, Zurawski G, Banchereau J, Oh SK.Concomitant activation and antigen uptake via human Dectin-1 results in potent antigen-specific CD8+ T Cell responses. J Immunol2010;185:3504-13.

Igyártó BZ, Haley K, Ortner D, Bobr A, Gerami-Nejad M, Edelson BT, Zurawski SM, Malissen B, Zurawski G, Berman J, Kaplan DH. Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses. Immunity 2011;35:260-72.

Li D, Romain G, Flamar AL, Duluc D, Dullaers M, Li XH, Zurawski S, Bosquet N, Palucka AK, Le Grand R, O'Garra A, Zurawski G, Banchereau J, Oh S. Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10-producing suppressive CD4+ T cells. J Exp Med 2012;16:109-21.


 



Baylor Health Care System is located in Dallas, Texas