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Center of Metabolomics

What is Metabolomics?

Metabolomics is the quantitative measurement of small-molecule metabolites (metabolic Intermediates, hormones and other signaling molecules, and secondary metabolites) found in a biological sample. Metabolomes are considered to be down stream of both gene and protein expression and reflect both transcriptional and translational processes. Metabolic profiling provides insight into intra- and extra-cellular regulatory processes involved in metabolic adaption for each individual phenotype.

 

Approaches

Within our center, we apply liquid chromatography and gas chromatography mass spectrometry techniques to perform targeted and general metabolomic studies.

 

  • Targeted metabolomics: enables the systematic quantitation of a wide range of metabolites in cells, tissues or clinically relevant fluids. This analytical approach has the advantage of being highly specific and sensitive, providing high quality data on the molar concentrations of multiple metabolites involved in a pathway. Targeted metabolomic analysis generally requires a hypothesis-driven type of experiment, where there is a recognized rationale for the determination of a group of metabolites. 
  • General metabolomics: (also known as untargeted metabolomics) is an analytical approach used to determine potential biomarkers in a disease group in comparison to a non-disease or control group.

 

Current Metabolomic Biomarker Projects

 

Capabilities & Resources

 



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