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Lawrence Sweetman, Ph.D

Co-Director, Center of Metabolomics



Contact Information:
Phone: 214-820-3895

Ph.D. Biochemistry, University of Miami, Florida
American Board of Medical Genetics, Biochemical Geneticist
Fellow American College of Medical Genetics

Other appointments:

Adjunct Professor of Biomedical Studies, Baylor University

Research Interests:

  • Novel treatments for fatty acid oxidation disorders and other metabolic disorders involving energy metabolism
  • Develop improved diagnostic tests for inborn errors of metabolism and other metabolic disorders with UPLC MS/MS (ultra high pressure liquid chromatography tandem mass spectrometry) and GCxGC-TOF-MS (two dimensional gas chromatography time-of-flight mass spectrometry
  • Mass spectrometric metabolomics of various body fluids to identify possible biomarkers of cancer and metabolic disorders which may be of value in early diagnosis or in monitoring treatment
  • Development of personalized medicine clinical tests from biomarkers suggested by metabolomic findings


Current Research:

  • Biochemical responses (organic acids and acylcarnitines) in clinical studies of triheptanoin (anaplerotic substrate) for nutritional therapy of long-chain fatty acid oxidation disorders
  • Quantification of D- and L-isomers of 2-hydroxyglutaric acid in relation to change of function mutant isocitrate dehydrogenase in patients with glioma or acute myelogenous leukemia for diagnosis and treatment/relapse monitoring, using chiral column GCxGC-TOF-MS
  • Plasma and urine metabolomics of living liver donors during liver regeneration using GCxGC-TOF-MS

Plasma and urine metabolomics of living liver donors dur





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