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Skip Navigation LinksBaylor Health CareResearchBaylor Scott & White Research InstituteDallasResearch Institutes and CentersBaylor Center for Gastrointestinal Cancer ResearchCurrent FundingElevated D-2-hydroxyglutarate precedes and promotes tumor progression in inflammatory bowel diseases

Elevated D-2-hydroxyglutarate precedes and promotes tumor progression in inflammatory bowel diseases

 

 

 

Grant number: RP150638

Principal Investigator: Arianne L. Theiss

Funding Organization: Cancer Prevention Research Institute of Texas (CPRIT)

Project Start: 07/01/2015

Project End: 06/30/2017

 

Abstract:

The goals of this proposal are to determine whether elevated levels of D-2-HG during colitis drive progression to colorectal cancer and to define the role and therapeutic potential of targeting EglN1/Hif1a/D-2-HGDH pathway in colitis-associated cancer.



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