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Giovanni Filardo, PhD, MPH

 

 

Director of Epidemiology, Office of the Chief Quality Officer, Baylor Scott & White Health, Dallas, TX

 

The Bradley Family Endowed Chair in Cardiovascular Epidemiology, Baylor University Medical Center, Dallas, TX

 

Director of Cardiovascular Epidemiology, The Heart Hospital Baylor, Plano, TX

 

Dr. Filardo is an NIH and AHRQ-funded Principal Investigator.  As 2017, Dr. Filardo is serving as the BSWH Principal Investigator in the All of Us Research Program as a member of the Trans-America Consortium – a collaborative of 4 integrated delivery networks that span 7 states. The All of Us Research Program is a historic effort to gather data from one million or more people living in the United States to accelerate research and improve health. By taking into account individual differences in lifestyle, environment, and biology, researchers will uncover paths toward delivering precision medicine.

 

If you are interested in participating in the All of Us Research Program or want more information, click here: All of Us

 

In 2014, Dr. Filardo received a 2-year $500,000 grant from Gilead Sciences, Inc., to investigate Ranolazine’s potential to prevent short- and long-term re-hospitalizations after cardiac catheterization/percutaneous coronary intervention, and the associated impact on costs of care.

 

As of 2013, Dr. Filardo is also a co-investigator on the NHLBI–funded Baylor Core Clinic Center for the Cardiothoracic Surgical Network (CTSN), which seeks to establish a cooperative network of cardiac surgery programs to promulgate the use of evidence-based medicine in surgical practice.

 

In 2011, Dr. Filardo received a 3-year, $2.3 million grant from NIH / National Heart Lung Blood Institute for the study Post-CABG Atrial Fibrillation.

 

In 2010, Dr. Filardo received a 3-year, $700,000 grant from the Agency for Healthcare Research and Quality for the study Large Population-based Study of Surgery for Abdominal Aortic Aneurysms.

 

In 2009, Dr. Filardo was among the 5 finalists for the American Heart Association QCOR Young Investigator Award for his study showing the direct and significant effect of new-onset post-CABG AF on long term survival.

 

Dr. Filardo is the Director of Epidemiology within the Baylor Scott & White Health Office of the Chief Quality Officer, the Bradley Family Endowed Chair in Cardiovascular Epidemiology at Baylor University Medical Center, and the Director of Cardiovascular Epidemiology at the Heart Hospital Baylor Plano. Currently, he is leading/collaborating on over 60 research projects, the majority involving multiple sites/centers, including three randomized trials. He has published over 130 manuscripts and presented his research results at more than 30 conferences. Dr. Filardo’s research predominantly focuses on outcomes of cardiac surgery.

 

Dr. Filardo also serves as a Clinical Professor of Health Services Research at Baylor University, Research Associate Professor of Statistics II at Southern Methodist University, Adjunct Professor of Medicine at University of Louisville, KY, and Adjunct Associate Professor of Epidemiology at the University of North Texas, Fort Worth, TX. Dr. Filardo received his PhD in Epidemiology with a concentration in cardiovascular disease from Yale University and has worked with several world leaders in cardiothoracic surgery, cardiology, and epidemiology, including Dr. Alessandro Liberati at the Italian Cochrane Center, Dr. Ballard at Emory University and at Baylor, Dr. Harlan Krumholz at Yale University, Drs. Paul Grayburn, and William Roberts at Baylor University Medical Center and the Baylor Heart Hospital, Dr. Clyde Yancy at Northwestern University, and Drs. Shahian, Damiano, and Mack at Massachusetts General Hospital, Washington University, and Baylor, respectively. Dr. Filardo has a strong record of research pertaining to the quality and safety of medical care and has conducted key research into understanding the patterns of care and patient outcomes in cardiovascular disease, particularly with respect to patients undergoing cardiac surgery. In 2006, his work in the field of cardiothoracic surgery risk model development led to an invitation to serve as an associate member of the STS Quality Measurement Task Force responsible for developing mortality and morbidity models for the STS Workforce. Since 2016, Dr. Filardo serves in the STS Participant User File Research Program Task Force in charge of streamlining and facilitating National Database participant-led research. Dr. Filardo also serves on the American Journal of Cardiology Editorial Board as an Associate Editor.

 

Dr. Filardo has a strong record of research pertaining to the quality and safety of medical care and has conducted key research into understanding the patterns of care and outcomes of patients with cardiovascular disease. He is experienced in study design, data collection, data management and analysis, and manuscript preparation.

 

Publications on ResearchGate through PubMed

 

 

Research Support

Ongoing Research (selected)

 

2017- All of Us Research Program

 

This large epidemiologic study seeks to establish a national research cohort of 1 million participants within which research at the intersection of human biology, behavior, genetics, environment, data science and computation, and much more will be conducted with the goal of developing more effective ways to prolong health and treat disease.  

 

Role: BSWH Principal Investigator

Amount: $1,800,000

2014-2018 Gilead Sciences (IN-US-259-1332)

 

Effectiveness of ranolazine at admission and/or discharge in reducing re-admissions after PCI

 

This population-based, multi-site observational study will provide important information about ranolazine’s potential to prevent short- and long-term re-hospitalizations after cardiac catheterization/PCI, and the associated impact on costs of care. This information will be useful in updating clinical guidelines/best practices for patients undergoing cardiac catheterization/PCI, and to decision-makers setting policies regarding the indications for and re-imbursement coverage of ranolazine as a prophylactic and/or therapeutic agent. 

 

Role: Principal Investigator

Amount: $492,000

 

2013-2018

NIH / National Heart Lung Blood Institute (UM-HL117922)


Baylor Core Clinic Center for the Cardiothoracic Surgical Network


The goal of the Cardiothroacic Surgery Network (CTSN) is to establish a cooperative network of cardiac surgery programs to promulgate the use of evidence-based medicine in surgical practice. The Network is intended to design, conduct, and analyze important, randomized clinical trials and observational studies, disseminate the results and thereby translate the findings into clinical practice. We will be responsible for successfully executing and completing CTSN multi-center clinical trials and observational studies.


Role: Co-Investigator

Amount: $1,951,898

 

2011-2017

NIH / National Heart Lung Blood Institute (R01HL103683)

 

New-onset Post-CABG Atrial Fibrillation 

 

This is a large multicenter observational study which includes 32,420 consecutive patients without pre-operative AF who underwent isolated CABG between 1/1/1997 and 12/31/2008 at Baylor University Medical Center (Dallas, TX), Emory University (Atlanta, GA), University of Virginia (Charlottesville, VA), and Washington University (St. Louis, MO) using data from the STS database, patient medical records, administrative data, and the Social Security Administration Death Master File.  The study seeks to evaluate the effectiveness of the prophylaxis and management strategies for new-onset AF following isolated CABG and their impact on long-term survival (>15 years).  

 

Role: Principal Investigator

Amount:  $2,330,042

 

2013-2017

Baylor Foundation and Baylor Heart and Vascular Institute

 

A meta-analysis comparing short and long-term mortality between patients undergoing off-pump and on-pump isolated coronary artery bypass graft surgery

 

This is a comprehensive meta-analysis assessing the association between OPCAB (vs on-pump CABG) and short and long term mortality in patients undergoing isolated CABG.  The project will analyze results from over 150 studies and the cohort will comprise over 1.5 million patients who underwent isolated CABG in various programs worldwide between 1992 and 2013.

 

Role: Co-Principal Investigator

Amount:  $9,339

 

2013-2017

Baylor Foundation and Baylor Heart and Vascular Institute

 

A meta-analysis assessing the effectiveness of pre-operative beta blockers use in patients undergoing isolated coronary artery bypass graft surgery

 

This is a comprehensive meta-analysis assessing the association between β-blocker use (vs not) and short-term mortality in patients undergoing isolated CABG. The study cohort will comprise over 1 million patients who underwent isolated CABG in various cardiac programs worldwide between 1990 and 2013.

 

Role: Co-Principal Investigator

Amount: $9,339

 

2006-2017

Baylor Foundation and Baylor Heart and Vascular Institute

 

Risk of adverse outcomes following cardiac surgery: Risk models

 

The goal of the study is to build predictive models to accurately estimate patients’ risk for adverse events following coronary artery bypass graft (CABG) and other cardiac surgeries.  Primary outcomes of interest are: mortality (operative and in-hospital), stroke, acute renal failure, deep sternal wound infection, re-operation, and prolonged ventilation.  The study also aims to provide a statistical tool to predict length of stay following isolated CABG and to accurately assess the impact of BMI on the probability of adverse events following this surgery. 

 

Role: Principal Investigator         

Amount:  $21,500

 

2012-2017  

Discovery Foundation

 

New-onset post-CABG Atrial fibrillation and survival in women

 

This is a retrospective population-based multicenter study assessing the effectiveness of optimal preventive and management strategies and their impact on incidence of new-onset post- CABG atrial fibrillation and long-term survival in women.

 

Role: Co-Investigator

Amount:  $99,695

 

2014-2017

Baylor Foundation and Baylor Heart and Vascular Institute

 

The role of established pre-operative risk factors in predicting long-term survival in patients undergoing cardiac surgery: Risk models

 

The goal of the study is to build predictive models to accurately estimate patients’ risk for long-term adverse events following coronary artery bypass graft (CABG) and other cardiac surgeries.  Primary outcomes of interest are: mortality (operative and in-hospital), stroke, acute renal failure, deep sternal wound infection, re-operation, and prolonged ventilation. 

 

Role: Principal Investigator          

Amount:  $37,800

 

2011-2016  Baylor Foundation and Baylor Heart and Vascular Institute

 

Comparing long-term survival between patients undergoing off-pump and on-pump coronary artery bypass graft surgery

 

This a retrospective cohort study assessing the association between off-pump coronary artery bypass graft surgery (OPCAB) (vs on-pump CABG) and long term survival in patients undergoing isolated CABG.  The study cohort will comprise over 200,000 patients who underwent isolated CABG at any US programs participating in the STS Adult Cardiac Surgery Database between 1997 and 2008.  The primary outcome of interest is: Survival, measured as time (in days) to either death or last follow-up from date of surgery. 

 

Role: Principal Investigator

Amount:  $9,000

 

2009-2016

Baylor Foundation and Baylor Heart and Vascular Institute

 

Optimal management of new-onset post-operative atrial fibrillation and long-term survival in patients undergoing isolated CABG

 

This study will focus primarily on assessing the association between new-onset post-CABG AFIB (AFIB with optimal management / AFIB without optimal management / no AFIB) and long term survival. The primary outcome of interest is: Survival, measured as time (in days) to either death or last follow-up (February 1, 2009) from date of surgery.  The exposure of interest is:  New-onset post-operative atrial fibrillation defined as new atrial fibrillation during hospitalization following isolated CABG as classified by the STS Adult Cardiac Surgery Database that received optimal therapy (or not) as indicated by the ACC/AHA/ESC guidelines regarding the management of new-onset atrial fibrillation.

 

Role: Principal Investigator

Amount:  $15,500

 

2010-2016  Baylor Foundation and Baylor Heart and Vascular Institute

 

Gender and race survival differences after CABG

 

The goal of the proposed study is to assess the association of gender and race and long-term survival in a cohort of 8,000 consecutive patients who underwent CABG at Baylor University Medical Center, Dallas, TX between 1/1/1997-12/31/2009. 

 

Role: Principal Investigator

Amount:  $9,000

 

2008-2016   Baylor Foundation and Baylor Heart and Vascular Institute

 

A randomized trial assessing the association between type of local anesthesia treatment and postoperative pain in patients having undergone arrhythmia surgery       

 

The goal of the study is to investigate the relationship between two standard treatments, lidocaine or a mixture of lidocaine and marcaine, and 1) postoperative pain; 2) narcotic use following pacemaker or defibrillator insertion in consecutive subjects who undergo arrhythmia surgery at Baylor Heart and Vascular Institute. 

 

Role: Principal Investigator

Amount:  $50,000

 

2008-2016

Baylor Foundation and Baylor Heart and Vascular Institute

 

Association between body fatness (BMI and BSA) and risk of post-operative atrial fibrillation in patients undergoing isolated CABG

 

The goal of the study is to investigate the relationship between BMI (and BSA) and AFIB using a propensity-adjusted model, controlling for risk factors identified by the Society of Thoracic Surgeons and other clinical/non-clinical details and avoiding the categorization of BMI and BSA in 7,027 consecutive subjects who underwent isolated CABG at Baylor University Medical Center (Dallas, TX) between 1/1/1997 and 12/31/2006. 

 

Role: Principal Investigator         

Amount:  $7,500

 

2013-2016 

Baylor Foundation and Baylor Heart and Vascular Institute

 

Incidence of Endoleak in Open versus Endovascular Abdominal Aortic Aneurysm Repair

 

This is a retrospective cohort study assessing whether the association between surgical treatment and re-operation, rupture, and post-discharge mortality differs by AAA morphology in patients undergoing elective AAA repair.  The study cohort will comprise 485 patients who underwent surgery at Baylor University Medical Center between January 2002 and December 2011.

 

Role: Co-Principal Investigator

Amount: $19,742

 

 

Completed Research (selected)

 

2006-2014

Baylor Foundation and Baylor Heart and Vascular Institute

 

Risk of adverse outcomes following cardiac surgery: Risk models

 

The goal of the study is to build predictive models to accurately estimate patients’ risk for adverse events following coronary artery bypass graft (CABG) and other cardiac surgeries.  Primary outcomes of interest are: mortality (operative and in-hospital), stroke, acute renal failure, deep sternal wound infection, re-operation, and prolonged ventilation.  The study also aims to provide a statistical tool to predict length of stay following isolated CABG and to accurately assess the impact of BMI on the probability of adverse events following this surgery. 

 

Role: Principal Investigator         

Amount:  $21,500

 

2010-2013

NIH / AHRQ (R01HS018576)

 

A large population-based study of surgery for abdominal aortic aneurysms        

 

This is a large multicenter population based study assessing compliance of abdominal aortic aneurysms surgeries (endovascular and open) with clinical guidelines over eight years and outcomes.  Additionally, the study addresses the question of management of small abdominal aortic aneurysms – particularly regarding the risks and benefits associated with immediate open surgical repair vs surveillance and selective surgery for aneurysm size and patient age subgroups within the clinical definition of small abdominal aortic aneurysms.  

 

Role: Principal Investigator

Amount:  $702,292

 

2009-2013 Merck Foundation

 

Community based partnerships: Addressing diabetes disparities in Dallas county

 

The objective of this project is to implement a health equity diabetes disease management program to serve patients treated by physicians participating in Project Access Dallas.

 

Role: Co-Investigator

Amount:  $2,502,292

 

2007-2011         Baylor Foundation and Baylor Heart and Vascular Institute

 

Long term survival following isolated mitral valve repair or replacement

 

The goal of the study is to investigate the relationship between isolated mitral valve surgery (repair or replacement) and mortality (in-hospital and long term) using a propensity-adjusted model, controlling for risk factors identified by the Society of Thoracic Surgeons and other clinical/non-clinical details in 349 consecutive subjects who underwent isolated mitral valve repair (n=149) or replacement (n=200) at Baylor University Medical Center (Dallas, TX) between 1/1/1997 and 11/30/2003.  Primary outcomes of interest are: mortality (operative, in-hospital, and long-term), re-operation, and stroke. 

 

Role: Principal Investigator

Amount:  $7,500

 

2009-2010         Baylor Foundation and Baylor Heart and Vascular Institute

 

New-onset post-operative atrial fibrillation and long term survival in patients undergoing aortic valve replacement            

 

The goal of the proposed study is to assess the association of new-onset post-AVR AFIB and long-term survival in a cohort of 6,050 consecutive patients without preoperative AFIB who underwent AVR at Baylor University Medical Center, Dallas, TX between 1/1/1997-12/31/2006.

 

Role: Principal Investigator

Amount:  $7,500

 

2006-2007        

NIH / AHRQ (1R13HS16493-01)

 

Measuring quality of care and patient safety: Problems in use and interpretation

 

The goals of this small conference grant are: 1) to bring together researchers from various organizations to discuss methodological problems inherent the assessment of quality of care and patient safety in low volume hospitals; 2) to stimulate researchers in developing solutions to the problems posed by small numbers related to low volume hospitals by promoting interaction, exchange of knowledge, including novel and best methodological approaches, and collaboration among researchers; and 3) to promote and stimulate participation of personnel from rural hospitals in a discussion forum with researchers, in order to formulate questions, discuss the answers, and collaborate to find solutions. 

 

Role: Co-Investigator and Member of the Scientific Committee

Amount:  $1,550,000 

 

2004-2007        

NIH / AHRQ (1UC1HS015431-01)

 

Rural hospital collaborative for excellence using IT

 

The goal of this project is to implement advanced health information technology and standardized national measures of care in rural and small community hospitals and to evaluate through a randomized trial across 60 hospitals in Texas the effectiveness of an educational intervention to enhance this health information technology implementation.

 

Role: Co-Investigator and Project Director       

Amount:  $50,000

 

 

 



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